Medtronic dorsal column stimulator array4/14/2024 Axial disability and deep brain stimulation in patients with Parkinson disease. Long term effects of bilateral subthalamic nucleus stimulation on cognitive function, mood, and behaviour in Parkinson’s disease. Success and problems of long-term levodopa therapy in Parkinson’s disease. Falls in Parkinson’s disease: a complex and evolving picture. Prevalence of gait disorders in hospitalized neurological patients. The prevalence of freezing of gait in Parkinson’s disease and in patients with different disease durations and severities. This neuroprosthesis opens new perspectives to reduce the severity of locomotor deficits in people with PD. We found that the neuroprosthesis interacted synergistically with deep brain stimulation of the subthalamic nucleus and dopaminergic replacement therapies to alleviate asymmetry and promote longer steps, improve balance and reduce freezing of gait. We then implanted the neuroprosthesis in a 62-year-old male with a 30-year history of PD who presented with severe gait impairments and frequent falls that were medically refractory to currently available therapies. This neuroprosthesis not only alleviated locomotor deficits but also restored skilled walking in this model. We first developed this neuroprosthesis in a non-human primate model that replicates locomotor deficits due to PD. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dorsal root entry zones innervating lumbosacral segments to reproduce the natural spatiotemporal activation of the lumbosacral spinal cord during walking. People with late-stage Parkinson’s disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. Nature Medicine volume 29, pages 2854–2865 ( 2023) Cite this article A spinal cord neuroprosthesis for locomotor deficits due to Parkinson’s disease
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